Sedil 5mg Tablet | Uses | Side- Effects | Interaction | 10pcs | ePharma
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Sedil 5mg Tablet

Generic: Diazepam

Type: Tablet

Pack Size: 20pcs

  • Sedil 5mg Tablet (Diazepam) is a prescription medication used to treat anxiety, seizures, muscular spasms, and symptoms of alcohol withdrawal.
  • The major element in Sedil 5 is diazepam. Diazepam is a benzodiazepine that regulates the balance of substances in the brain.
  • Discontinuing the medicine quickly might result in rebound anxiety, in which a person experiences anxiety symptoms that are worse than previously.
  • It is critical to provide the doctor with a comprehensive medical history. The medication is typically used for 8 to 12 weeks.

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✅ Description:

Sedil 5 is a medication belonging to the Benzodiazepine (BZD) group. It is primarily used to treat severe anxiety disorder, muscle spasms, seizures, and alcohol withdrawal symptoms. It may also be given before surgery to alleviate anxiety. Anxiety disorder is a mental condition characterized by excessive fear or worry that impacts daily activities and can lead to panic attacks.

The active ingredient in Sedil 5 is Diazepam, which works by increasing the levels of a calming chemical called gamma-aminobutyric acid (GABA) in the brain. This helps relieve anxiety, prevent seizures, and relax tense muscles. Sedil 5 can also temporarily treat insomnia caused by an anxiety disorder. Its off-label uses include alcohol withdrawal syndrome, insomnia, panic disorder, and chemotherapy-associated nausea and vomiting. However, it is not recommended for mild to moderate anxiety related to everyday life.

It is important to use Sedil 5 only as prescribed by a doctor. The duration of treatment will depend on your medical condition. Common side effects may include daytime drowsiness, lightheadedness, unsteadiness, or dizziness. These side effects usually resolve over time and do not require medical attention. However, if they persist, you should consult your doctor.

It is crucial not to stop taking Sedil 5 without consulting your doctor, as it may cause withdrawal symptoms. Avoid using this medication if you have lung disease, muscle weakness (myasthenia gravis), sleep apnea, severe liver disease, or problems with alcohol or other recreational drugs. Sedil 5 has the potential for dependence, so it is important to seek medical advice before discontinuing its use. Withdrawal symptoms may include anxiety, increased heart rate, tremors, or a general feeling of being unwell. If you are pregnant or breastfeeding, inform your doctor, as they will assess the benefits and potential risks before prescribing the medication. Lastly, it is advised not to drive or operate machinery while taking Sedil 5, as it can reduce mental alertness.

Safety Advices


Alcohol
UNSAFE

Do not consume alcohol while taking Sedil 5mg Tablet as it increases the sedative effect of Sedil 5mg Tablet and leads to fall injuries and makes you very sleepy.


Pregnancy
UNSAFE

Sedil 5mg Tablet your doctor if you are pregnant or planning pregnancy. The doctor can advise the best according to your situation.


Breastfeeding
UNSAFE

Breastfeeding mothers should not take Sedil 5mg Tablet as it can pass through the milk and might have harmful effects on the baby. Please inform the doctor if you are breastfeeding.


Driving
UNSAFE

Sedil 5mg Tablet can induce sleep and drowsiness. Please do not drive after taking Sedil 5mg Tablet to be safe.


Kidney
CONSULT YOUR DOCTOR

Sedil 5mg Tablet should be used with caution in patients suffering from severe kidney failure. Consult your doctor before taking it.


Liver
CAUTION

Sedil 5mg Tablet is not recommended for use in patients suffering from severe liver disease. Consult your doctor before taking it.

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✔️ Uses of Sedil 5mg Tablet
  • Anxiety disorder
  • Short-term anxiety
  • Pre-operative anxiety
✔️ How does Sedil 5mg Tablet work?

Sedil 5mg Tablet belongs to benzodiazepines which work by binding to specific receptors in the brain and enhancing the activity of an inhibitory neurotransmitter (a chemical in the brain) called GABA which is involved in sleep induction, memory, anxiety, epilepsy, and neuronal excitability.

✔️ Side Effect of Sedil 5mg Tablet
  • Drowsiness
  • Dizziness
  • Blurred vision
  • Tiredness
  • Constipation
  • Confusion
✔️ Quick Suggestions:
  • Sedil 5mg Tablet is indeed used to treat short-term anxiety, but it is important to note that its safety for long-term use has not been established. It is not recommended to use Sedil 5mg Tablet for more than 4 weeks. This medication has a high potential for addiction and habit formation, so it should only be taken as prescribed by your doctor in terms of dosage and duration.
  • One common side effect of Sedil 5mg Tablet is dizziness. It is advised not to engage in activities such as driving or tasks that require mental focus until you understand how the medication affects you.
  • There are several lifestyle strategies that can help in managing anxiety. Regular exercise is known to release endorphins, improve sleep, and boost self-image, thus helping to lower anxiety levels. Finding humor in daily life, such as watching comedy shows, can also help relieve stress.
  • Mindfulness techniques, including yoga, meditation, cognitive therapy, and mindfulness-based stress reduction, can increase awareness and promote relaxation.
  • It is important to stay hydrated by drinking enough water and to limit or avoid alcohol and caffeine, as these substances can exacerbate anxiety symptoms.
  • A diet rich in whole grains, vegetables, and fruits is recommended over-consuming processed foods that contain many simple carbohydrates. Including herbs like turmeric, ginger, and chamomile in your meals can be beneficial due to their anti-inflammatory properties.
  • Reducing alcohol, caffeine, added sugar, high salt, and high-fat intake, especially trans fats, may also help reduce inflammation and manage anxiety.
  • Incorporating antioxidants into your daily diet, such as ashwagandha, omega-3 fatty acids, green tea, and lemon balm, can be beneficial.
  • Spending time with friends and family and maintaining a strong social network may help lower the risk of anxiety.
  • If you are pregnant, planning to conceive, or breastfeeding, it is important to inform your doctor about your condition, as they will consider the potential risks and benefits before prescribing any medication.
  • It is crucial not to abruptly stop taking the medication without consulting your doctor, as this may lead to withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, sweating, tremors, and confusion. Always follow your doctor's guidance when it comes to discontinuing medication.
✔️ Indication of Sedil 5mg Tablet

Sedil is a short-term medication used to treat mild to moderate anxiety, excitement, agitation, fear, aggressiveness, and other symptoms. Anxiety responses can be produced by stressful conditions, anxiety states with bodily symptoms, abrupt alcohol withdrawal, status epilepticus, premedication for surgical operations, febrile convulsions, and restlessness in hospitalized patients.

✔️ Pharmacology

Sedil, which is also known as diazepam, binds to a specific site on the GABA receptor in the brain. By doing so, it enhances the action of GABA, a neurotransmitter that inhibits brain activity. This leads to the opening of chloride ion channels in cells, resulting in a calming effect.

When diazepam is taken orally, it is rapidly and completely absorbed by the body. It takes approximately 15-90 minutes for the concentration of diazepam in the blood plasma to reach its peak. The average plasma half-life of diazepam is about 30 hours, indicating that it takes this amount of time for the concentration of diazepam in the plasma to reduce by half.

Diazepam is highly bound to proteins in the plasma, with approximately 98-99 percent of the drug being bound. Only small amounts of the unchanged drug are eliminated in the urine after diazepam is metabolized in the liver. A small percentage of the metabolites are excreted through the bile into the gut and ultimately eliminated in the feces.

When diazepam is administered rectally in suppository form, it is also significantly absorbed by the body. The peak concentration of diazepam in the blood plasma is reached within 1.5-2 hours after rectal administration.

These pharmacokinetic properties describe the absorption, distribution, metabolism, and elimination of diazepam in the body, providing insights into how the drug is processed and utilized by the body after administration.

✔️ Dosage & Administration of Sedil 5mg Tablet

Dosages of Sedil 5mg Tablet for various indications are as follows:

Adult Dose:

Anxiety: 

  • 2-10 mg orally every 6-12 hours, or 2-10 mg intravenously or intramuscularly every 6-12 hours. The maximum recommended dose is 30 mg every 8 hours.

Alcohol Withdrawal: 

  • 10 mg orally every 6-8 hours during the first 24 hours, then reduce to 5 mg orally every 6-8 hours as needed. Alternatively, the initial intravenous or intramuscular dose is 10 mg, with additional doses of 5-10 mg every 6-8 hours as needed.

Endoscopy: 

  • The intravenous dose should be titrated to 10 mg or less immediately before the procedure, not exceeding a cumulative dose of 20 mg. For intramuscular administration, 5-10 mg is given 30 minutes before the procedure.

Preoperative Sedation: 

  • 10 mg intramuscularly before surgery.

Sedation in the ICU: 

  • 5-10 mg intravenously 1-2 hours before surgery, with additional doses of 0.03-0.1 mg/kg every 30 minutes to 6 hours.
  • Muscle Spasm:
  • 2-10 mg orally every 6-8 hours as needed, or 5-10 mg intravenously or intramuscularly initially, followed by doses of 5-10 mg every 3-4 hours if necessary.

Seizure Disorder: 

  • 2-10 mg orally every 6-12 hours as an adjunct, or 0.2 mg/kg per rectum, repeated after 4-12 hours as needed.

Status Epilepticus: 

  • 5-10 mg intravenously or intramuscularly every 5-10 minutes, not exceeding a total dose of 30 mg. Alternatively, for rectal administration, 0.5 mg/kg is given initially, followed by 0.25 mg/kg in 10 minutes as needed.

Child Dose:

Sedative/Muscle Relaxant: 

  • The potentially toxic dose in patients under 6 years is greater than 0.5 mg/kg. For patients over 12 years, the recommended dose is 0.12-0.8 mg/kg orally divided every 6-8 hours, or 0.04-0.2 mg/kg intravenously or intramuscularly every 2-4 hours, not exceeding 0.6 mg/kg within 8 hours.

Status Epilepticus: 

  • The potentially toxic dose in patients under 6 years is greater than 0.5 mg/kg per rectum.
  • The recommended doses are as follows: 2-6 years: 0.5 mg/kg, repeat in 4-12 hours as needed; 6-12 years: 0.3 mg/kg, repeat in 4-12 hours as needed; over 12 years: 0.2 mg/kg, repeat in 4-12 hours as needed. For intravenous administration, the recommended doses are 6 months-5 years: 0.2-0.5 mg initially, repeat every 2-5 minutes, not exceeding 5 mg; may repeat 2-4 hours later as needed; over 5 years: 1 mg given slowly every 2-5 minutes, not exceeding a total dose of 10 mg; may repeat in 2-4 hours if necessary.

Renal Dose:

  • Dose reduction may be required in patients with renal impairment.

Elderly patients should not exceed half the adult dose, and dose reduction may be required in patients with hepatic impairment.

Take Sedil 5mg Tablet as advised by your physician. Swallow Sedil 5mg Tablet with a glass of water. Do not crush or chew the medicine. Your doctor will decide the exact dose and duration of treatment for you depending on your age, body weight, and disease condition.

✔️ Interaction

Sedil 5mg Tablet can potentially interact with various medications and disease conditions. Here is a summary of the interactions:

Drug Interactions:

  • Antianxiety or antiepileptic medicines (carbamazepine, fluvoxamine, phenobarbital, phenytoin, primidone)
  • Anti-HIV drugs (amprenavir, ritonavir)
  • Acidity medicine (cimetidine)
  • Medications for chronic alcoholism (disulfiram)
  • Antibiotics (rifampicin)
  • Anti-Parkinson's drug (levodopa)
  • Asthma drugs (theophylline)
  • Central nervous system depressant drugs
  • Opioid analgesics or pain killers

Food Interactions:

  • Grapefruit and grapefruit juice
  • Caffeine-containing food or drinks

Disease Interactions:

  • Obesity
  • Acute alcohol intoxication
  • Closed-angle glaucoma
  • Drug addiction
  • Kidney/liver disease
  • Respiratory depression
  • Prolonged low blood pressure
  • Muscle disease (myasthenia gravis)
  • Severe seizures (fits)
✔️ Contraindications

Diazepam (the active ingredient in Sedil) should not be used in certain conditions, including:

  • Myasthenia Gravis: Diazepam can worsen muscle weakness in individuals with myasthenia gravis, a neuromuscular disorder.
  • Pulmonary Insufficiency: Diazepam can cause respiratory depression, so it should be avoided in individuals with pulmonary insufficiency or severe respiratory impairment.
  • Respiratory Depression: Diazepam can further suppress respiratory function, so caution is required or it should be avoided in individuals with respiratory depression.
  • Benzodiazepine Allergy: If an individual has a known allergy to benzodiazepines, including diazepam, they should not use this medication.
✔️ Precautions & Warnings
  • Impaired Renal and Hepatic Function: Caution is advised in individuals with impaired kidney or liver function, as the clearance of diazepam may be reduced. Dose adjustments may be necessary.
  • Respiratory Disease: Diazepam can cause respiratory depression, so it should be used with caution in individuals with respiratory diseases, such as chronic obstructive pulmonary disease (COPD).
  • Organic Cerebral Changes: Diazepam should be used with caution in individuals with organic cerebral changes, such as brain damage or brain disorders.
  • Elderly Patients: Elderly individuals may be more sensitive to the effects of diazepam, including sedation and cognitive impairment. Lower doses may be required.
  • Psychotic Patients: Diazepam should be used cautiously in individuals with psychosis, as it may worsen their condition.
  • Epileptics: Diazepam can lower the seizure threshold, so caution is needed when using it in individuals with a history of epilepsy or seizures.
  • History of Alcohol or Drug Addiction: Diazepam has the potential for abuse and addiction, so it should be used with caution in individuals with a history of alcohol or drug addiction.
  • Impaired Gag Reflex: Diazepam can impair the gag reflex, which is important for protecting the airway. Caution is advised in individuals with impaired gag reflexes.
  • Obesity: Diazepam may have prolonged effects in obese individuals due to its lipophilic properties. Close monitoring and dose adjustments may be necessary.
  • CNS Depression: Diazepam can cause central nervous system (CNS) depression, leading to drowsiness and impaired cognitive function. Activities requiring focus and attention, such as driving, should be avoided.
  • Abrupt Discontinuation: Abruptly stopping diazepam can lead to withdrawal symptoms. It is important to gradually reduce the dosage under the guidance of a healthcare professional.
  • Alcohol Consumption: Alcohol should be avoided while taking diazepam, as it can increase the sedative effects and potentially lead to dangerous side effects.
  • Pregnancy and Lactation: Diazepam is not recommended during pregnancy or while breastfeeding due to potential risks to the fetus or infant. Discuss with your doctor about alternative medications.
  • Addiction Risk: Diazepam has a high potential for addiction and dependence. It should only be taken as prescribed and under the supervision of a healthcare professional.
  • Pediatric Use: The safety and efficacy of diazepam in children vary depending on the specific formulation and age group. The use of diazepam in children should be discussed with a healthcare professional.
✔️ Storage Conditions

Sedil 5mg Tablet should be stored at room temperature and away from any source of direct heat or light. Sedil 5mg Tablet should not be placed in direct sunlight. You do not need to store the medicine in the refrigerator. Make sure to keep the medicine away from the reach of children and pets at home.

Frequently Asked Questions (FAQ)

Sedil 5mg Tablet is prescribed for anxiety disorder and short term anxiety. So, if Sedil 5mg Tablet is prescribed for more than 4 weeks, your doctor may reduce the dose before stopping to prevent further withdrawal symptoms.

Regular intake of Sedil 5mg Tablet can impact your memory including a lack of focus or concentration, or complete ‘black out’ difficult to remember important things.

If you have taken a double dose or overdose of Sedil 5mg Tablet, you need immediate medical help either by calling the doctor or going to the nearest hospital or clinic.

Sedil 5mg Tablet includes Diazepam, which works by boosting levels of a relaxing chemical in your brain known as gamma-aminobutyric acid (GABA), which helps to ease anxiety, halt seizures attacks (fits), and relax tense muscles. Furthermore, Sedil 5mg Tablet helps transitory insomnia (sleeplessness) caused by an anxiety illness. Sedil 5mg Tablet off-label applications include alcohol withdrawal syndrome, sleeplessness, panic disorder, and chemotherapy-associated nausea and vomiting.

Do not stop taking Sedil 5mg Tablet suddenly, if you stop taking Sedil 5mg Tablet suddenly you may experience withdrawal symptoms such as excitement or depression, nervousness, sleeping difficulties, sweating, irritability, diarrhoea, upset stomach, reoccurrence and worsening of symptoms.

It depends on what you are taking Sedil 5mg Tablet for. If you are taking it to treat anxiety, you should start feeling better within a few hours, but it may take a week or two before the full benefits become evident. Similarly, if you are taking it to relieve muscle spasm you may notice a difference after 15 minutes. Your muscles will start relaxing when you keep taking Sedil 5mg Tablet regularly for a few days.

No, using clozapine and Sedil 5mg Tablet together is not advised since the effects of both medications may interact. This can cause a significant drop in blood pressure, breathing issues (respiratory depression), and possibly the death of your heart.

The dose in elderly is generally half of the dose recommended to young people. This is because Sedil 5mg Tablet causes muscle relaxation which can make the patient fall down, which may further lead to fractures.
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ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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